|Other Names||Kaptin, Actin-associated protein 2E4, KPTN|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Necessary for normal neuromorphogenesis. May be involved in actin dynamics. May play a role in producing the sensory apparatus in hair cells. May play a role in actin rearrangements that accompany platelet activation and stereocilia formation.|
|Cellular Location||Cytoplasm. Cytoplasm, perinuclear region. Cell projection, stereocilium. Cell projection, growth cone Note=Perinuclear at the tips of stereocilium in the inner ear Localized at sites of actin polymerization in motile fibroblasts and neuronal growth cones|
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KPTN may be involved in actin dynamics. May play a role in producing the sensory apparatus in hair cells. May play a role in actin rearrangements that accompany platelet activation and stereocilia formation.
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Bearer, E.L., et al. Ann. Hum. Genet. 64 (PT 3), 189-196 (2000) :Bearer, E.L., et al. Eur. J. Cell Biol. 78(2):117-126(1999)Bearer, E.L. J. Neurosci. 12(3):750-761(1992)
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