|Other Names||Sorting nexin-15, SNX15|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN.|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side|
|Tissue Location||Widely expressed.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the sorting nexin family.Members of this family contain a phox (PX) domain, which is aphosphoinositide binding domain, and are involved in intracellulartrafficking. Overexpression of this gene results in a decrease inthe processing of insulin and hepatocyte growth factor receptors totheir mature subunits. This decrease is caused by themislocalization of furin, the endoprotease responsible for cleavageof insulin and hepatocyte growth factor receptors. This protein isinvolved in endosomal trafficking from the plasma membrane torecycling endosomes or the trans-Golgi network. This gene encodestwo transcript variants encoding distinct isoforms. [provided byRefSeq].
Venter, J.C., et al. Science 291(5507):1304-1351(2001)Phillips, S.A., et al. J. Biol. Chem. 276(7):5074-5084(2001)Barr, V.A., et al. Traffic 1(11):904-916(2000)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.