|Other Names||Sorting nexin-15, SNX15|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN.|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side|
|Tissue Location||Widely expressed.|
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This gene encodes a member of the sorting nexin family.Members of this family contain a phox (PX) domain, which is aphosphoinositide binding domain, and are involved in intracellulartrafficking. Overexpression of this gene results in a decrease inthe processing of insulin and hepatocyte growth factor receptors totheir mature subunits. This decrease is caused by themislocalization of furin, the endoprotease responsible for cleavageof insulin and hepatocyte growth factor receptors. This protein isinvolved in endosomal trafficking from the plasma membrane torecycling endosomes or the trans-Golgi network. This gene encodestwo transcript variants encoding distinct isoforms. [provided byRefSeq].
Venter, J.C., et al. Science 291(5507):1304-1351(2001)Phillips, S.A., et al. J. Biol. Chem. 276(7):5074-5084(2001)Barr, V.A., et al. Traffic 1(11):904-916(2000)
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