|Other Names||Peroxisomal acyl-coenzyme A oxidase 2, 3-alpha, 7-alpha, 12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase, 3-alpha, 7-alpha, 12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase, Trihydroxycoprostanoyl-CoA oxidase, THCA-CoA oxidase, THCCox, ACOX2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids.|
|Tissue Location||Present in all tissues tested: heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Most abundant in heart, liver and kidney|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the acyl-CoA oxidasefamily. It encodes the branched-chain acyl-CoA oxidase which isinvolved in the degradation of long branched fatty acids and bileacid intermediates in peroxisomes. Deficiency of this enzymeresults in the accumulation of branched fatty acids and bile acidintermediates, and may lead to Zellweger syndrome, severe mentalretardation, and death in children.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Rikova, K., et al. Cell 131(6):1190-1203(2007)Wanders, R.J., et al. Annu. Rev. Biochem. 75, 295-332 (2006) :Moghrabi, N.N., et al. Biochem. Biophys. Res. Commun. 231(3):767-769(1997)Baumgart, E., et al. Ann. N. Y. Acad. Sci. 804, 678-679 (1996) :
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