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USP17L2 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q6R6M4
Clone Names 100617077
Peptide ID 100617077
Additional Information
Gene ID 377630
Other Names Ubiquitin carboxyl-terminal hydrolase 17, USP17, Deubiquitinating enzyme 17-like protein 2, Deubiquitinating protein 3, DUB-3, Ubiquitin carboxyl-terminal hydrolase 17-like protein 2, Ubiquitin thioesterase 17-like protein 2, Ubiquitin-specific-processing protease 17-like protein 2, USP17L2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name USP17L2
Function Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors DDX58 and IFIH1 stimulates the cellular response to viral infection.
Cellular Location Nucleus. Endoplasmic reticulum
Tissue Location Broadly expressed.
Research Areas
Citations (0)

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DUB3 is a member of the ubiquitin processing protease(UBP) subfamily of deubiquitinating enzymes. See USP1 (MIM 603478)for background information.


Pereg, Y., et al. Nat. Cell Biol. 12(4):400-406(2010)Alkan, C., et al. Nat. Genet. 41(10):1061-1067(2009)Burrows, J.F., et al. J. Biol. Chem. 279(14):13993-14000(2004)

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$ 80.00
Cat# BP16721b
Availability: In Stock
Bulk Size
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