USP17L2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q6R6M4 |
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Clone Names | 100617077 |
Gene ID | 377630 |
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Other Names | Ubiquitin carboxyl-terminal hydrolase 17, USP17, Deubiquitinating enzyme 17-like protein 2, Deubiquitinating protein 3, DUB-3, Ubiquitin carboxyl-terminal hydrolase 17-like protein 2, Ubiquitin thioesterase 17-like protein 2, Ubiquitin-specific-processing protease 17-like protein 2, USP17L2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | USP17L2 |
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Function | Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors RIGI and IFIH1 stimulates the cellular response to viral infection. |
Cellular Location | Nucleus. Endoplasmic reticulum |
Tissue Location | Broadly expressed.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
DUB3 is a member of the ubiquitin processing protease(UBP) subfamily of deubiquitinating enzymes. See USP1 (MIM 603478)for background information.
References
Pereg, Y., et al. Nat. Cell Biol. 12(4):400-406(2010)Alkan, C., et al. Nat. Genet. 41(10):1061-1067(2009)Burrows, J.F., et al. J. Biol. Chem. 279(14):13993-14000(2004)
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