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ARX Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96QS3 |
|---|---|
| Clone Names | 100617085 |
| Gene ID | 170302 |
|---|---|
| Other Names | Homeobox protein ARX, Aristaless-related homeobox, ARX |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ARX |
|---|---|
| Function | Transcription factor (PubMed:22194193, PubMed:31691806). Binds to specific sequence motif 5'-TAATTA-3' in regulatory elements of target genes, such as histone demethylase KDM5C (PubMed:22194193, PubMed:31691806). Positively modulates transcription of KDM5C (PubMed:31691806). Activates expression of KDM5C synergistically with histone lysine demethylase PHF8 and perhaps in competition with transcription regulator ZNF711; synergy may be related to enrichment of histone H3K4me3 in regulatory elements (PubMed:31691806). Required for normal brain development (PubMed:11889467, PubMed:12379852, PubMed:14722918). Plays a role in neuronal proliferation, interneuronal migration and differentiation in the embryonic forebrain (By similarity). May also be involved in axonal guidance in the floor plate (By similarity). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138} |
| Tissue Location | Expressed predominantly in fetal and adult brain and skeletal muscle. Expression is specific to the telencephalon and ventral thalamus. There is an absence of expression in the cerebellum throughout development and also in adult. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a homeobox-containing gene expressed duringdevelopment. The expressed protein contains two conserved domains,a C-peptide (or aristaless domain) and the prd-like class homeoboxdomain. It is a member of the group-II aristaless-related proteinfamily whose members are expressed primarily in the central and/orperipheral nervous system. This gene is thought to be involved inCNS development. Mutations in this gene cause X-linked mentalretardation and epilepsy.
References
Shoubridge, C., et al. Hum. Mutat. 31(8):889-900(2010)Fullston, T., et al. Eur. J. Hum. Genet. 18(2):157-162(2010)Nabbout, R., et al. Epilepsy Res. 87(1):25-30(2009)Kitamura, K., et al. Hum. Mol. Genet. 18(19):3708-3724(2009)Price, M.G., et al. J. Neurosci. 29(27):8752-8763(2009)
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