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APPBP2 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q92624
Clone Names 100617137
Additional Information
Gene ID 10513
Other Names Amyloid protein-binding protein 2, Amyloid beta precursor protein-binding protein 2, APP-BP2, Protein interacting with APP tail 1, APPBP2, KIAA0228, PAT1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name APPBP2 {ECO:0000303|PubMed:26138980, ECO:0000312|HGNC:HGNC:622}
Function Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:29775578). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29779948, PubMed:29775578). The CRL2(APPBP2) complex specifically recognizes proteins with a -Arg-Xaa- Xaa-Gly degron at the C-terminus, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:29775578). The CRL2(APPBP2) complex mediates ubiquitination and degradation of truncated SELENOV selenoproteins produced by failed UGA/Sec decoding, which end with a -Arg-Xaa-Xaa-Gly degron (PubMed:26138980). May play a role in intracellular protein transport: may be involved in the translocation of APP along microtubules toward the cell surface (PubMed:9843960).
Cellular Location Nucleus. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Associated with membranes and microtubules.
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene interacts withmicrotubules and is functionally associated with beta-amyloidprecursor protein transport and/or processing. The beta-amyloidprecursor protein is a cell surface protein with signal-transducingproperties, and it is thought to play a role in the pathogenesis ofAlzheimer's disease. This gene has been found to be highlyexpressed in breast cancer. Multiple polyadenylation sites havebeen found for this gene.

References

Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Benboudjema, L., et al. J. Virol. 77(17):9192-9203(2003)Gao, Y., et al. Proc. Natl. Acad. Sci. U.S.A. 98(26):14979-14984(2001)Monni, O., et al. Proc. Natl. Acad. Sci. U.S.A. 98(10):5711-5716(2001)Barlund, M., et al. Cancer Res. 60(19):5340-5344(2000)

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$ 277.78
Cat# BP16727c
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