|Other Names||Amyloid protein-binding protein 2, Amyloid beta precursor protein-binding protein 2, APP-BP2, Protein interacting with APP tail 1, APPBP2, KIAA0228, PAT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.|
|Cellular Location||Nucleus. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein Note=Associated with membranes and microtubules|
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The protein encoded by this gene interacts withmicrotubules and is functionally associated with beta-amyloidprecursor protein transport and/or processing. The beta-amyloidprecursor protein is a cell surface protein with signal-transducingproperties, and it is thought to play a role in the pathogenesis ofAlzheimer's disease. This gene has been found to be highlyexpressed in breast cancer. Multiple polyadenylation sites havebeen found for this gene.
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Benboudjema, L., et al. J. Virol. 77(17):9192-9203(2003)Gao, Y., et al. Proc. Natl. Acad. Sci. U.S.A. 98(26):14979-14984(2001)Monni, O., et al. Proc. Natl. Acad. Sci. U.S.A. 98(10):5711-5716(2001)Barlund, M., et al. Cancer Res. 60(19):5340-5344(2000)
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