|Other Names||Chloride channel protein 2, ClC-2, CLCN2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Ubiquitously expressed. Moderately expressed in aortic and coronary vascular smooth muscle cells and expressed at a low level in aortic endothelial cells|
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The transmembrane protein encoded by this gene is avoltage-gated chloride channel that maintains chloride ionhomeostasis in various cells. Defects in this gene may be a causeof certain epilepsies. Four transcript variants encoding differentisoforms have been found for this gene.
Scheper, G.C., et al. Genet Test Mol Biomarkers 14(2):255-257(2010)Cornejo, I., et al. J. Cell. Physiol. 221(3):650-657(2009)Thompson, C.H., et al. J. Biol. Chem. 284(38):26051-26062(2009)Kleefuss-Lie, A., et al. Nat. Genet. 41(9):954-955(2009)Klaus, F., et al. Biochem. Biophys. Res. Commun. 381(3):407-411(2009)
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