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CLCN2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P51788 |
|---|---|
| Clone Names | 100617168 |
| Gene ID | 1181 |
|---|---|
| Other Names | Chloride channel protein 2, ClC-2, CLCN2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CLCN2 |
|---|---|
| Function | Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage- gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis (PubMed:29403011, PubMed:29403012). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Ubiquitously expressed. Moderately expressed in aortic and coronary vascular smooth muscle cells and expressed at a low level in aortic endothelial cells. Expressed in the adrenal gland, predominantly in the zona glomerulosa (PubMed:29403011) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The transmembrane protein encoded by this gene is avoltage-gated chloride channel that maintains chloride ionhomeostasis in various cells. Defects in this gene may be a causeof certain epilepsies. Four transcript variants encoding differentisoforms have been found for this gene.
References
Scheper, G.C., et al. Genet Test Mol Biomarkers 14(2):255-257(2010)Cornejo, I., et al. J. Cell. Physiol. 221(3):650-657(2009)Thompson, C.H., et al. J. Biol. Chem. 284(38):26051-26062(2009)Kleefuss-Lie, A., et al. Nat. Genet. 41(9):954-955(2009)Klaus, F., et al. Biochem. Biophys. Res. Commun. 381(3):407-411(2009)
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