|Other Names||Dual specificity protein kinase CLK2, CDC-like kinase 2, CLK2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.|
|Cellular Location||Isoform 1: Nucleus. Nucleus speckle. Note=Inhibition of phosphorylation at Ser-142 results in accumulation in the nuclear speckle.|
|Tissue Location||Endothelial cells.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the CLK family of dualspecificity protein kinases. CLK family members have been shown tointeract with, and phosphorylate, serine- and arginine-rich (SR)proteins of the spliceosomal complex, which is a part of theregulatory mechanism that enables the SR proteins to control RNAsplicing. Note that this gene is distinct from TELO2 gene(GeneID:9894), which shares CLK2 and hCLK2 symbol aliases in commonwith this gene, but encodes a protein that is involved in telomerelength regulation.
Nam, S.Y., et al. J. Biol. Chem. 285(41):31157-31163(2010)Eisenreich, A., et al. Circ. Res. 104(5):589-599(2009)Rendtlew Danielsen, J.M., et al. J. Biol. Chem. 284(7):4140-4147(2009)Castle, J.C., et al. Nat. Genet. 40(12):1416-1425(2008)Jin, J., et al. Curr. Biol. 14(16):1436-1450(2004)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.