|Other Names||Receptor-type tyrosine-protein phosphatase N2, R-PTP-N2, Islet cell autoantigen-related protein, IAR, ICAAR, Phogrin, PTPRN2, KIAA0387|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Implicated in development of nervous system and pancreatic endocrine cells.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I membrane protein|
|Tissue Location||Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal chord|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of theprotein tyrosine phosphatase (PTP) family. PTPs are known to besignaling molecules that regulate a variety of cellular processesincluding cell growth, differentiation, mitotic cycle, andoncogenic transformation. This PTP possesses an extracellularregion, a single transmembrane region, and a single intracellularcatalytic domain, and thus represents a receptor-type PTP. Thecatalytic domain of this PTP is most closely related toPTPRN/IA-2beta. This PTP and PTPRN are both found to be majorautoantigens associated with insulin-dependent diabetes mellitus.Three alternatively spliced transcript variants of this gene, whichencode distinct proteins, have been reported.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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