|Other Names||Receptor-type tyrosine-protein phosphatase N2, R-PTP-N2, Islet cell autoantigen-related protein, IAR, ICAAR, Phogrin, PTPRN2, KIAA0387|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Implicated in development of nervous system and pancreatic endocrine cells.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I membrane protein|
|Tissue Location||Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal chord|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of theprotein tyrosine phosphatase (PTP) family. PTPs are known to besignaling molecules that regulate a variety of cellular processesincluding cell growth, differentiation, mitotic cycle, andoncogenic transformation. This PTP possesses an extracellularregion, a single transmembrane region, and a single intracellularcatalytic domain, and thus represents a receptor-type PTP. Thecatalytic domain of this PTP is most closely related toPTPRN/IA-2beta. This PTP and PTPRN are both found to be majorautoantigens associated with insulin-dependent diabetes mellitus.Three alternatively spliced transcript variants of this gene, whichencode distinct proteins, have been reported.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.