|Other Names||Dual specificity tyrosine-phosphorylation-regulated kinase 1B, Minibrain-related kinase, Mirk protein kinase, DYRK1B, MIRK|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC).|
|Tissue Location||Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
DYRK1B is a member of the DYRK family of protein kinases.DYRK1B contains a bipartite nuclear localization signal and isfound mainly in muscle and testis. The protein is proposed to beinvolved in the regulation of nuclear functions. Three isoforms ofDYRK1B have been identified differing in the presence of twoalternatively spliced exons within the catalytic domain. [providedby RefSeq].
Lauth, M., et al. Nat. Struct. Mol. Biol. 17(6):718-725(2010)Yang, C., et al. Carcinogenesis 31(4):552-558(2010)Jin, K., et al. J. Biol. Chem. 284(34):22916-22925(2009)Deng, X., et al. Cancer Res. 69(8):3317-3324(2009)Janumyan, Y., et al. J. Biol. Chem. 283(49):34108-34120(2008)
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