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DRD2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P14416 |
|---|---|
| Clone Names | 100507190 |
| Gene ID | 1813 |
|---|---|
| Other Names | D(2) dopamine receptor, Dopamine D2 receptor, DRD2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DRD2 |
|---|---|
| Function | Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (PubMed:21645528). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein |
| Tissue Location | [Isoform 1]: Expressed in the anterior pituitary gland. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes the D2 subtype of the dopamine receptor.This G-protein coupled receptor inhibits adenylyl cyclase activity.A missense mutation in this gene causes myoclonus dystonia; othermutations have been associated with schizophrenia. Alternativesplicing of this gene results in two transcript variants encodingdifferent isoforms. A third variant has been described, but it hasnot been determined whether this form is normal or due to aberrantsplicing.
References
Verma, V., et al. J. Biol. Chem. 285(45):35092-35103(2010)Borroto-Escuela, D.O., et al. Biochem. Biophys. Res. Commun. 401(4):605-610(2010)Stelzel, C., et al. J. Neurosci. 30(42):14205-14212(2010)Huang, H.Y., et al. J. Formos. Med. Assoc. 109(10):736-739(2010)Itokawa, M., et al. J. Pharmacol. Sci. 114(1):1-5(2010)
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