|Other Names||D(2) dopamine receptor, Dopamine D2 receptor, DRD2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the D2 subtype of the dopamine receptor.This G-protein coupled receptor inhibits adenylyl cyclase activity.A missense mutation in this gene causes myoclonus dystonia; othermutations have been associated with schizophrenia. Alternativesplicing of this gene results in two transcript variants encodingdifferent isoforms. A third variant has been described, but it hasnot been determined whether this form is normal or due to aberrantsplicing.
Verma, V., et al. J. Biol. Chem. 285(45):35092-35103(2010)Borroto-Escuela, D.O., et al. Biochem. Biophys. Res. Commun. 401(4):605-610(2010)Stelzel, C., et al. J. Neurosci. 30(42):14205-14212(2010)Huang, H.Y., et al. J. Formos. Med. Assoc. 109(10):736-739(2010)Itokawa, M., et al. J. Pharmacol. Sci. 114(1):1-5(2010)
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