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ARHGEF5 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q12774
Clone Names 100603017
Peptide ID 100603017
Additional Information
Gene ID 7984
Other Names Rho guanine nucleotide exchange factor 5, Ephexin-3, Guanine nucleotide regulatory protein TIM, Oncogene TIM, Transforming immortalized mammary oncogene, p60 TIM, ARHGEF5, TIM
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ARHGEF5
Synonyms TIM
Function Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity).
Cellular Location Cytoplasm. Nucleus. Cell projection, podosome {ECO:0000250|UniProtKB:E9Q7D5}
Tissue Location Ubiquitously expressed with highest levels in placenta. High levels are also found in colon, kidney, trachea, prostate, liver, pancreas, pituitary gland, thyroid gland and mammary gland. In fetal tissues, expressed at high levels in kidney, lung and liver (PubMed:15601624). Expressed at low levels in lung and heart (PubMed:14662653).
Research Areas
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Background

Rho GTPases play a fundamental role in numerous cellularprocesses initiated by extracellular stimuli that work through Gprotein coupled receptors. The encoded protein may form a complexwith G proteins and stimulate Rho-dependent signals. This proteinmay be involved in the control of cytoskeletal organization.

References

Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Wang, Z., et al. J. Biol. Chem. 284(42):28599-28606(2009)Lin, Y.M., et al. Mol. Carcinog. 47(12):925-933(2008)Zhang, Y., et al. Mol. Cell Proteomics 4(9):1240-1250(2005)

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$ 80.00
Cat# BP16745b
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