|Other Names||Protein GREB1, Gene regulated in breast cancer 1 protein, GREB1, KIAA0575|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.|
|Cellular Location||Membrane; Single-pass membrane protein|
|Tissue Location||Expressed in proliferating prostatic tissue and prostate cancer.|
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This gene is an estrogen-responsive gene that is an earlyresponse gene in the estrogen receptor-regulated pathway. It isthought to play an important role in hormone-responsive tissues andcancer. Three alternatively spliced transcript variants encodingdistinct isoforms have been found for this gene. [provided byRefSeq].
Hnatyszyn, H.J., et al. Breast Cancer Res. Treat. 122(2):371-380(2010)Trynka, G., et al. Gut 58(8):1078-1083(2009)Rittie, L., et al. Arch Dermatol 144(9):1129-1140(2008)Sun, J., et al. Mol. Endocrinol. 21(11):2651-2662(2007)Deschenes, J., et al. J. Biol. Chem. 282(24):17335-17339(2007)
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