|Other Names||Reticulocalbin-1, RCN1, RCN|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.|
|Cellular Location||Endoplasmic reticulum lumen.|
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Reticulocalbin 1 is a calcium-binding protein located inthe lumen of the ER. The protein contains six conserved regionswith similarity to a high affinity Ca(+2)-binding motif, theEF-hand. High conservation of amino acid residues outside of thesemotifs, in comparison to mouse reticulocalbin, is consistent with apossible biochemical function besides that of calcium binding. Inhuman endothelial and prostate cancer cell lines this proteinlocalizes to the plasma membrane.
Favor, J., et al. Genetics 182(4):1077-1088(2009)Hansen, G.A., et al. Mol. Cell. Biochem. 320 (1-2), 25-33 (2009) :Cooper, C.R., et al. J. Cell. Biochem. 104(6):2298-2309(2008)Lim, J., et al. Cell 125(4):801-814(2006)Taylor, T.D., et al. Nature 440(7083):497-500(2006)
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