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ZNRF1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8ND25
Clone Names 110617147
Peptide ID 110617147
Additional Information
Gene ID 84937
Other Names E3 ubiquitin-protein ligase ZNRF1, 632-, Nerve injury-induced gene 283 protein, Zinc/RING finger protein 1, ZNRF1, NIN283
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZNRF1
Synonyms NIN283
Function E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable).
Cellular Location Endosome. Lysosome. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Note=Associated with synaptic vesicle membranes in neurons
Tissue Location Expressed primarily in the nervous system, with expression higher in developing brain relative to adult Expressed at low levels in testis and thymus
Research Areas
Citations (0)

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In a study identifying genes in rat that are upregulatedin response to nerve damage, a gene which is highly expressed inganglia and in the central nervous system was found. The proteinencoded by the rat gene contains both a zinc finger and a RINGfinger motif and is localized in the endosome/lysosome compartment,indicating that it may be involved in ubiquitin-mediated proteinmodification. The protein encoded by this human gene is highlysimilar in sequence to that encoded by the rat gene. [provided byRefSeq].


Dastani, Z., et al. Eur. J. Hum. Genet. 18(3):342-347(2010)Yoshida, K., et al. Biochem. Biophys. Res. Commun. 389(3):506-511(2009)Markson, G., et al. Genome Res. 19(10):1905-1911(2009)van Wijk, S.J., et al. Mol. Syst. Biol. 5, 295 (2009) :Araki, T., et al. J. Neurosci. 23(28):9385-9394(2003)

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$ 80.00
Cat# BP16755c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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