|Other Names||E3 ubiquitin-protein ligase ZNRF1, 632-, Nerve injury-induced gene 283 protein, Zinc/RING finger protein 1, ZNRF1, NIN283|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable).|
|Cellular Location||Endosome. Lysosome. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Note=Associated with synaptic vesicle membranes in neurons|
|Tissue Location||Expressed primarily in the nervous system, with expression higher in developing brain relative to adult Expressed at low levels in testis and thymus|
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In a study identifying genes in rat that are upregulatedin response to nerve damage, a gene which is highly expressed inganglia and in the central nervous system was found. The proteinencoded by the rat gene contains both a zinc finger and a RINGfinger motif and is localized in the endosome/lysosome compartment,indicating that it may be involved in ubiquitin-mediated proteinmodification. The protein encoded by this human gene is highlysimilar in sequence to that encoded by the rat gene. [provided byRefSeq].
Dastani, Z., et al. Eur. J. Hum. Genet. 18(3):342-347(2010)Yoshida, K., et al. Biochem. Biophys. Res. Commun. 389(3):506-511(2009)Markson, G., et al. Genome Res. 19(10):1905-1911(2009)van Wijk, S.J., et al. Mol. Syst. Biol. 5, 295 (2009) :Araki, T., et al. J. Neurosci. 23(28):9385-9394(2003)
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