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PPIL1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y3C6 |
|---|---|
| Clone Names | 110617281 |
| Gene ID | 51645 |
|---|---|
| Other Names | Peptidyl-prolyl cis-trans isomerase-like 1, PPIase, Rotamase PPIL1, PPIL1, CYPL1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PPIL1 |
|---|---|
| Synonyms | CYPL1 |
| Function | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346, PubMed:33220177). PPIases accelerate the folding of proteins. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:16595688). Catalyzes prolyl peptide bond isomerization in CDC40/PRP17 (PubMed:33220177). Plays an important role in embryonic brain development; this function is independent of its isomerase activity (PubMed:33220177). |
| Cellular Location | Nucleus |
| Tissue Location | Ubiquitous, with the most abundant expression in heart and skeletal muscle |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the cyclophilin family ofpeptidylprolyl isomerases (PPIases). The cyclophilins are a highlyconserved, ubiquitous family, members of which play an importantrole in protein folding, immunosuppression by cyclosporin A, andinfection of HIV-1 virions. Based on similarity to other PPIases,this protein could accelerate the folding of proteins and mightcatalyze the cis-trans isomerization of proline imidic peptidebonds in oligopeptides.
References
Wang, X., et al. J. Biol. Chem. 285(7):4951-4963(2010)Xu, C., et al. J. Biol. Chem. 281(23):15900-15908(2006)Xu, C., et al. J. Biomol. NMR 31(2):179-180(2005)Mungall, A.J., et al. Nature 425(6960):805-811(2003)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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