|Other Names||G1/S-specific cyclin-E2, CCNE2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Essential for the control of the cell cycle at the late G1 and early S phase.|
|Tissue Location||According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor- derived cells compared to non-transformed proliferating cells According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon|
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The protein encoded by this gene belongs to the highlyconserved cyclin family, whose members are characterized by adramatic periodicity in protein abundance through the cell cycle.Cyclins function as regulators of CDK kinases. Different cyclinsexhibit distinct expression and degradation patterns whichcontribute to the temporal coordination of each mitotic event. Thiscyclin forms a complex with and functions as a regulatory subunitof CDK2. This cyclin has been shown to specifically interact withCIP/KIP family of CDK inhibitors, and plays a role in cell cycleG1/S transition. The expression of this gene peaks at the G1-Sphase and exhibits a pattern of tissue specificity distinct fromthat of cyclin E1. A significantly increased expression level ofthis gene was observed in tumor-derived cells. [provided byRefSeq].
Cunningham, J.M., et al. Br. J. Cancer 101(8):1461-1468(2009)Dapas, B., et al. Mol. Med. 15 (9-10), 297-306 (2009) :Caldon, C.E., et al. Mol. Cell. Biol. 29(17):4623-4639(2009)Masamha, C.P., et al. Cancer Res. 69(16):6565-6572(2009)Wu, Z., et al. Neoplasia 11(1):66-76(2009)
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