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DNAI1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UI46 |
|---|---|
| Clone Names | 110617308 |
| Gene ID | 27019 |
|---|---|
| Other Names | Dynein intermediate chain 1, axonemal, Axonemal dynein intermediate chain 1, DNAI1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DNAI1 |
|---|---|
| Function | Part of the dynein complex of respiratory cilia. |
| Cellular Location | Dynein axonemal particle. Cytoplasm, cytoskeleton, cilium axoneme |
| Tissue Location | Expressed in respiratory ciliated cells (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
The inner- and outer-arm dyneins, which bridge between thedoublet microtubules in axonemes, are the force-generating proteinsresponsible for the sliding movement in axonemes. The intermediateand light chains, thought to form the base of the dynein arm, helpmediate attachment and may also participate in regulating dyneinactivity. This gene encodes an intermediate chain dynein, belongingto the large family of motor proteins. Mutations in this generesult in abnormal ciliary ultrastructure and function associatedwith primary ciliary dyskinesia (PCD) and Kartagener syndrome.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Leigh, M.W., et al. Curr. Opin. Pediatr. 21(3):320-325(2009)Zuccarello, D., et al. Hum. Reprod. 23(8):1957-1962(2008)Failly, M., et al. Respiration 76(2):198-204(2008)Zariwala, M.A., et al. Am. J. Respir. Crit. Care Med. 174(8):858-866(2006)
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