|Other Names||Dynein intermediate chain 1, axonemal, Axonemal dynein intermediate chain 1, DNAI1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Part of the dynein complex of respiratory cilia.|
|Cellular Location||Cytoplasm, cytoskeleton, cilium axoneme.|
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The inner- and outer-arm dyneins, which bridge between thedoublet microtubules in axonemes, are the force-generating proteinsresponsible for the sliding movement in axonemes. The intermediateand light chains, thought to form the base of the dynein arm, helpmediate attachment and may also participate in regulating dyneinactivity. This gene encodes an intermediate chain dynein, belongingto the large family of motor proteins. Mutations in this generesult in abnormal ciliary ultrastructure and function associatedwith primary ciliary dyskinesia (PCD) and Kartagener syndrome.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Leigh, M.W., et al. Curr. Opin. Pediatr. 21(3):320-325(2009)Zuccarello, D., et al. Hum. Reprod. 23(8):1957-1962(2008)Failly, M., et al. Respiration 76(2):198-204(2008)Zariwala, M.A., et al. Am. J. Respir. Crit. Care Med. 174(8):858-866(2006)
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