|Other Names||Transient receptor potential cation channel subfamily V member 5, TrpV5, Calcium transport protein 2, CaT2, Epithelial calcium channel 1, ECaC, ECaC1, Osm-9-like TRP channel 3, OTRPC3, TRPV5, ECAC1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)- dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).|
|Cellular Location||Apical cell membrane; Multi-pass membrane protein. Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells (By similarity). The expression of the glycosylated form in the cell membrane is increased in the presence of WNK3.|
|Tissue Location||Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum.|
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This gene is a member of the transient receptor family andthe TrpV subfamily. The calcium-selective channel encoded by thisgene has 6 transmembrane-spanning domains, multiple potentialphosphorylation sites, an N-linked glycosylation site, and 5 ANKrepeats. This protein forms homotetramers or heterotetramers and isactivated by a low internal calcium level.
Chamoux, E., et al. J. Biol. Chem. 285(33):25354-25362(2010)Kennedy, B.G., et al. Mol. Vis. 16, 665-675 (2010) :Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)de Groot, T., et al. J. Am. Soc. Nephrol. 20(8):1693-1704(2009)Semenova, S.B., et al. Am. J. Physiol., Cell Physiol. 296 (5), C1098-C1104 (2009) :
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