|Other Names||Transient receptor potential cation channel subfamily V member 5, TrpV5, Calcium transport protein 2, CaT2, Epithelial calcium channel 1, ECaC, ECaC1, Osm-9-like TRP channel 3, OTRPC3, TRPV5, ECAC1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)- dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).|
|Cellular Location||Apical cell membrane; Multi-pass membrane protein. Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells (By similarity). The expression of the glycosylated form in the cell membrane is increased in the presence of WNK3.|
|Tissue Location||Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the transient receptor family andthe TrpV subfamily. The calcium-selective channel encoded by thisgene has 6 transmembrane-spanning domains, multiple potentialphosphorylation sites, an N-linked glycosylation site, and 5 ANKrepeats. This protein forms homotetramers or heterotetramers and isactivated by a low internal calcium level.
Chamoux, E., et al. J. Biol. Chem. 285(33):25354-25362(2010)Kennedy, B.G., et al. Mol. Vis. 16, 665-675 (2010) :Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)de Groot, T., et al. J. Am. Soc. Nephrol. 20(8):1693-1704(2009)Semenova, S.B., et al. Am. J. Physiol., Cell Physiol. 296 (5), C1098-C1104 (2009) :
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.