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FBXO5 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9UKT4
Clone Names 100525321
Peptide ID 100525321
Additional Information
Gene ID 26271
Other Names F-box only protein 5, Early mitotic inhibitor 1, FBXO5, EMI1, FBX5
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FBXO5
Synonyms EMI1, FBX5
Function Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding.
Cellular Location Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=In interphase, localizes in a punctate manner in the nucleus and cytoplasm with some perinuclear concentration. In mitotic cells, localizes throughout the cell, particularly at the spindle
Research Areas
Citations (0)

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This gene encodes a member of the F-box protein familywhich is characterized by an approximately 40 amino acid motif, theF-box. The F-box proteins constitute one of the four subunits ofthe ubiquitin protein ligase complex called SCFs(SKP1-cullin-F-box), which function in phosphorylation-dependentubiquitination. The F-box proteins are divided into 3 classes: Fbwscontaining WD-40 domains, Fbls containing leucine-rich repeats, andFbxs containing either different protein-protein interactionmodules or no recognizable motifs. The protein encoded by this genebelongs to the Fbxs class. This protein is similar to xenopus earlymitotic inhibitor-1 (Emi1), which is a mitotic regulator thatinteracts with Cdc20 and inhibits the anaphase promoting complex.Alternatively spliced transcript variants encoding differentisoforms have been identified.


Lei, S.F., et al. J. Bone Miner. Res. (2010) In press :Ma, H.T., et al. Mol. Cell. Biol. 29(24):6500-6514(2009)Lee, J., et al. Mol. Biol. Cell 20(7):1891-1902(2009)Gutgemann, I., et al. Mod. Pathol. 21(4):445-454(2008)Iwai, H., et al. Cell 130(4):611-623(2007)

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$ 80.00
Cat# BP16765c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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