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TOP3B Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O95985
Clone Names 100528220
Peptide ID 100528220
Additional Information
Gene ID 8940
Other Names DNA topoisomerase 3-beta-1, DNA topoisomerase III beta-1, TOP3B, TOP3B1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TOP3B
Synonyms TOP3B1
Function Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Possesses negatively supercoiled DNA relaxing activity.
Tissue Location Isoform 1 is found in testis, heart and skeletal muscle. A 4 kb transcript which probably represents isoform 2 is found in thymus, kidney and pancreas
Research Areas
Citations (0)

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This gene encodes a DNA topoisomerase, an enzyme thatcontrols and alters the topologic states of DNA duringtranscription. This enzyme catalyzes the transient breaking andrejoining of a single strand of DNA which allows the strands topass through one another, thus relaxing the supercoils and alteringthe topology of DNA. The enzyme interacts with DNA helicase SGS1and plays a role in DNA recombination, cellular aging andmaintenance of genome stability. Alternative splicing of theC-terminus of this gene results in three transcript variants whichhave distinct tissue specificity; however, not all variants havebeen fully described.


Oliveira-Costa, J.P., et al. Hum. Pathol. 41(11):1624-1630(2010)Lesch, K.P., et al. J Neural Transm 115(11):1573-1585(2008)Cho, Y.H., et al. Biochim. Biophys. Acta 1679(3):272-278(2004)Lehner, B., et al. Genome Res. 14(7):1315-1323(2004)Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :

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$ 80.00
Cat# BP16775b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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