|Other Names||Potassium voltage-gated channel subfamily KQT member 5, KQT-like 5, Potassium channel subunit alpha KvLQT5, Voltage-gated potassium channel subunit Kv75, KCNQ5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Strongly expressed in brain and skeletal muscle. In brain, expressed in cerebral cortex, occipital pole, frontal lobe and temporal lobe. Lower levels in hippocampus and putamen. Low to undetectable levels in medulla, cerebellum and thalamus|
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This gene is a member of the KCNQ potassium channel genefamily that is differentially expressed in subregions of the brainand in skeletal muscle. The protein encoded by this gene yieldscurrents that activate slowly with depolarization and can formheteromeric channels with the protein encoded by the KCNQ3 gene.Currents expressed from this protein have voltage dependences andinhibitor sensitivities in common with M-currents. They are alsoinhibited by M1 muscarinic receptor activation. Multiple transcriptvariants encoding different isoforms have been found for this gene.
Bailey, S.D., et al. Diabetes Care (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Roura-Ferrer, M., et al. Cell. Physiol. Biochem. 24 (5-6), 325-334 (2009) :Bal, M., et al. J. Biol. Chem. 283(45):30668-30676(2008)
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