|Other Names||Semaphorin-4A, Semaphorin-B, Sema B, SEMA4A, SEMAB, SEMB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
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This gene encodes a member of the semaphorin family ofsoluble and transmembrane proteins. Semaphorins are involved innumerous functions, including axon guidance, morphogenesis,carcinogenesis, and immunomodulation. The encoded protein is asingle-pass type I membrane protein containing animmunoglobulin-like C2-type domain, a PSI domain and a sema domain.It inhibits axonal extension by providing local signals to specifyterritories inaccessible for growing axons. It is an activator ofT-cell-mediated immunity and suppresses vascular endothelial growthfactor (VEGF)-mediated endothelial cell migration and proliferationin vitro and angiogenesis in vivo. Mutations in this gene areassociated with retinal degenerative diseases including retinitispigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10).Multiple alternatively spliced transcript variants encodingdifferent isoforms have been identified.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Schmidt-Kastner, R., et al. Mol. Vis. 14, 125-135 (2008) :Toyofuku, T., et al. EMBO J. 26(5):1373-1384(2007)Abid, A., et al. J. Med. Genet. 43(4):378-381(2006)Kumanogoh, A., et al. J. Cell. Sci. 116 (PT 17), 3463-3470 (2003) :
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