C8orf42 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q86YL5 |
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Clone Names | 100422271 |
Gene ID | 157695 |
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Other Names | Testis development-related protein, Protein INM01, TDRP, C8orf42 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TDRP |
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Synonyms | C8orf42 |
Function | Contributes to normal sperm motility, but not essential for male fertility. |
Cellular Location | Nucleus. Cytoplasm. Note=Mainly nuclear. Also detected in cytoplasm near the midpiece of the flagellum |
Tissue Location | Expressed in spermatogenic cells, especially in spermatocytes (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Made up of nearly 146 million bases, chromosome 8 encodes about 800 genes. Translocation of portions of chromosome 8 with amplifications of the c-Myc gene are found in some leukemias and lymphomas, and typically associated with a poor prognosis. Portions of chromosome 8 have been linked to schizophrenia and bipolar disorder. Trisomy 8, also known as Warkany syndrome 2, most often results in early miscarriage but is occasionally seen in a mosaic form in surviving patients who suffer to a varying degree from a number of symptoms including retarded mental and motor development, and certain facial and developmental defects. WRN is a DNA helicase encoded by chromosome 8 and shown defective in those with the early aging disorder Werner syndrome. Chromosome 8 is also associated with Pfeiffer syndrome, congenital hypothyroidism and Waardenburg syndrome. The C8orf42 gene product has been provisionally designated C8orf42 pending further characterization.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Wang, X., et al. Biochem. Biophys. Res. Commun. 394(1):29-35(2010)
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