|Other Names||Dynactin-associated protein, Full, DYNAP, C18orf26|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the regulation of cell proliferation. Promotes activation of the AKT1 signaling pathway. Promotes phosphorylation of AKT1 at 'Ser-473'.|
|Cellular Location||Golgi apparatus membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein. Note=Concentrated at cell-cell borders. Localizes at membranes in a microtubule-dependent manner|
|Tissue Location||Expressed in fibroblast and numerous cancer cell lines (at protein level). EMBL; AK096425; BAC04784.1; -; mRNA EMBL; AC091135; -; NOT_ANNOTATED_CDS; Genomic_DNA CCDS; CCDS11957.1; - RefSeq; NP_775900.1; NM_173629.2 UniGene; Hs.376146; - ProteinModelPortal; Q8N1N2; - STRING; 9606.ENSP00000315265; - PhosphoSitePlus; Q8N1N2; - BioMuta; DYNAP; - DMDM; 73620598; - PaxDb; Q8N1N2; - PRIDE; Q8N1N2; - Ensembl; ENST00000321600; ENSP00000315265; ENSG00000178690 GeneID; 284254; - KEGG; hsa:284254; - UCSC; uc002lfq.1; human CTD; 284254; - GeneCards; DYNAP; - HGNC; HGNC:26808; DYNAP HPA; HPA011148; - neXtProt; NX_Q8N1N2; - OpenTargets; ENSG00000178690; - PharmGKB; PA134946407; - eggNOG; ENOG410J4ES; Eukaryota eggNOG; ENOG4111DTF; LUCA GeneTree; ENSGT00400000022381; - HOGENOM; HOG000111950; - InParanoid; Q8N1N2; - OMA; NDQEAHS; - OrthoDB; EOG091G0NYO; - PhylomeDB; Q8N1N2; - TreeFam; TF338599; - BioCyc; ZFISH:ENSG00000178690-MONOMER; - GenomeRNAi; 284254; - PRO; PR:Q8N1N2; - Proteomes; UP000005640; Chromosome 18 Bgee; ENSG00000178690; - CleanEx; HS_C18orf26; - ExpressionAtlas; Q8N1N2; baseline and differential GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO; GO:0005886; C:plasma membrane; IDA:UniProtKB GO; GO:0032148; P:activation of protein kinase B activity; IDA:UniProtKB GO; GO:1901625; P:cellular response to ergosterol; IDA:UniProtKB GO; GO:0008284; P:positive regulation of cell proliferation; IDA:UniProtKB GO; GO:0042981; P:regulation of apoptotic process; IDA:UniProtKB InterPro; IPR031379; CLLAC Pfam; PF15675; CLLAC; 1 1: Evidence at protein level; Cell membrane; Complete proteome; Golgi apparatus; Membrane; Polymorphism; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix CHAIN 1 210 Dynactin-associated protein /FTId=PRO_0000079315 TOPO_DOM 1 113 Cytoplasmic. TRANSMEM 114 134 Helical; Signal-anchor for type II membrane protein. TOPO_DOM 135 210 Extracellular. COMPBIAS 172 207 Thr-rich VARIANT 38 38 V -> A (in dbSNP:rs35428499) /FTId=VAR_033751 VARIANT 189 189 T -> P (in dbSNP:rs9947055) /FTId=VAR_033752 SEQUENCE 210 AA; 22529 MW; E94FE6D340D3CF79 CRC64; MVADIKGNEQ IEKYSWREAC DTGSSRMDRK HGKYILNVEH SENQPPITHP NDQEAHSSIC WCLPSNDITS DVSPNLTGVC VNPGILAHSR CLQSESCNTQ VKEYCRNDWS MWKVFLACLL ACVIMTAIGV LIICLVNNKG SANSSIVIQL STNDGECVTV KPGTPSPACP PTMTTTSTVP ASTATESTTS TATAATTSTE PITVAPTDHL|
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Provided below are standard protocols that you may find useful for product applications.
C18orf26 (chromosome 18 open reading frame 26) is a 210 amino acid single pass membrane protein that is encoded by a gene which maps to human chromosome 18. Chromosome 18 houses over 300 protein-coding genes and contains nearly 76 million nucleotide bases. There are a variety of diseases associated with defects in chromosome 18-localized genes, some of which include Trisomy 18 (also known as Edwards syndrome), Niemann-Pick disease, hereditary hemorrhagic telangiectasia, erythropoietic protoporphyria and follicular lymphomas.
Kunoh, T., et al. Mol. Cancer Ther. 9(11):2934-2942(2010)
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