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NCAPD3 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P42695 |
|---|---|
| Clone Names | 100528294 |
| Gene ID | 23310 |
|---|---|
| Other Names | Condensin-2 complex subunit D3, Non-SMC condensin II complex subunit D3, hCAP-D3, NCAPD3, CAPD3, KIAA0056 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NCAPD3 {ECO:0000303|PubMed:27737959, ECO:0000312|HGNC:HGNC:28952} |
|---|---|
| Function | Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Condensin complexes I and II play essential roles inmitotic chromosome assembly and segregation. Both condensinscontain 2 invariant structural maintenance of chromosome (SMC)subunits, SMC2 (MIM 605576) and SMC4 (MIM 605575), but they containdifferent sets of non-SMC subunits. NCAPD3 is 1 of 3 non-SMCsubunits that define condensin II (Ono et al., 2003 [PubMed14532007]).
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Takemoto, A., et al. Nat. Struct. Mol. Biol. 16(12):1302-1308(2009)Lapointe, J., et al. Am. J. Surg. Pathol. 32(2):205-209(2008)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Seshadri, S., et al. BMC Med. Genet. 8 SUPPL 1, S15 (2007) :
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