|Other Names||Pleiotropic regulator 1, PLRG1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:28076346). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (PubMed:11101529, PubMed:11544257).|
|Cellular Location||Nucleus. Nucleus speckle|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
PLRG1 is necessary for spliceosome assembly and for pre-mRNA splicing.
Lleres, D., et al. EMBO Rep. 11(6):445-451(2010)Dehghan, A., et al. Circ Cardiovasc Genet 2(2):125-133(2009)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Andersen, J.S., et al. Nature 433(7021):77-83(2005)Ajuh, P., et al. Nucleic Acids Res. 31(21):6104-6116(2003)
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