|Other Names||Calcipressin-1, Adapt78, Down syndrome critical region protein 1, Myocyte-enriched calcineurin-interacting protein 1, MCIP1, Regulator of calcineurin 1, RCAN1, ADAPT78, CSP1, DSC1, DSCR1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ADAPT78, CSP1, DSC1, DSCR1|
|Function||Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556). Could play a role during central nervous system development (By similarity).|
|Tissue Location||Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues|
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The protein encoded by this gene interacts withcalcineurin A and inhibits calcineurin-dependent signalingpathways, possibly affecting central nervous system development.This gene is located in the minimal candidate region for the Downsyndrome phenotype, and is overexpressed in the brain of Downsyndrome fetuses. Chronic overexpression of this gene may lead toneurofibrillary tangles such as those associated with Alzheimerdisease. Three transcript variants encoding three differentisoforms have been found for this gene.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Tam, G.W., et al. Biochem. Soc. Trans. 38(2):445-451(2010)Lee, M.Y., et al. Hum. Mol. Genet. 19(3):468-479(2010)Sales, K.J., et al. Am. J. Pathol. 176(1):435-445(2010)Sales, K.J., et al. Biochim. Biophys. Acta 1793(12):1917-1928(2009)
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