|Other Names||MARCKS-related protein, MARCKS-like protein 1, Macrophage myristoylated alanine-rich C kinase substrate, Mac-MARCKS, MacMARCKS, MARCKSL1, MLP, MRP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity).|
|Cellular Location||Cytoplasm. Cell membrane. Note=Associates with the membrane via the insertion of the N-terminal N-myristoyl chain and the partial insertion of the effector domain. Association of the effector domain with membranes may be regulated by Ca(2+)/calmodulin (By similarity) In prostate cancers, detected in the cytoplasm and associated with apical or basal membranes (By similarity).|
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MARCKSL1 may be involved in coupling the protein kinase C and calmodulin signal transduction systems.
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Jordanova, A., et al. Nat. Genet. 38(2):197-202(2006)Ballif, B.A., et al. Mol. Cell Proteomics 3(11):1093-1101(2004)Ballif, B.A., et al. Mol. Cell Proteomics 3(11):1093-1101(2004)
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