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ARL1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P40616 |
|---|---|
| Clone Names | 100617112 |
| Gene ID | 400 |
|---|---|
| Other Names | ADP-ribosylation factor-like protein 1, ARL1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ARL1 |
|---|---|
| Function | GTP-binding protein that recruits several effectors, such as golgins, arfaptins and Arf-GEFs to the trans-Golgi network, and modulates their functions at the Golgi complex (PubMed:9624189, PubMed:21239483, PubMed:27436755, PubMed:22679020, PubMed:27373159). Plays thereby a role in a wide range of fundamental cellular processes, including cell polarity, innate immunity, or protein secretion mediated by arfaptins, which were shown to play a role in maintaining insulin secretion from pancreatic beta cells (PubMed:22981988). |
| Cellular Location | Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane. Membrane; Lipid-anchor |
| Tissue Location | Detected in heart, liver, lung and liver (at protein level). Detected in fetal heart, lung, liver and kidney Detected in adult heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the ARL(ADP-ribosylation factor-like) family of proteins, which arestructurally related to ADP-ribosylation factors (ARFs). ARFs,described as activators of cholera toxin (CT)ADP-ribosyltransferase activity, regulate intracellular vesicularmembrane trafficking, and stimulate a phospholipase D (PLD)isoform. Although, ARL proteins were initially thought not toactivate CT or PLD, later work showed that they are weakstimulators of PLD and CT in a phospholipid dependent manner.
References
Houghton, F.J., et al. Cell 138(4):787-794(2009)Nishimoto-Morita, K., et al. J. Biol. Chem. 284(16):10583-10592(2009)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Zahn, C., et al. Mol. Membr. Biol. 23(6):475-485(2006)Lu, L., et al. Mol. Biol. Cell 15(10):4426-4443(2004)
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