|Other Names||ADP-ribosylation factor-like protein 1, ARL1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus.|
|Cellular Location||Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Membrane; Lipid- anchor|
|Tissue Location||Detected in heart, liver, lung and liver (at protein level). Detected in fetal heart, lung, liver and kidney Detected in adult heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the ARL(ADP-ribosylation factor-like) family of proteins, which arestructurally related to ADP-ribosylation factors (ARFs). ARFs,described as activators of cholera toxin (CT)ADP-ribosyltransferase activity, regulate intracellular vesicularmembrane trafficking, and stimulate a phospholipase D (PLD)isoform. Although, ARL proteins were initially thought not toactivate CT or PLD, later work showed that they are weakstimulators of PLD and CT in a phospholipid dependent manner.
Houghton, F.J., et al. Cell 138(4):787-794(2009)Nishimoto-Morita, K., et al. J. Biol. Chem. 284(16):10583-10592(2009)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Zahn, C., et al. Mol. Membr. Biol. 23(6):475-485(2006)Lu, L., et al. Mol. Biol. Cell 15(10):4426-4443(2004)
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