|Other Names||Sex hormone-binding globulin, SHBG, Sex steroid-binding protein, SBP, Testis-specific androgen-binding protein, ABP, Testosterone-estradiol-binding globulin, TeBG, Testosterone-estrogen-binding globulin, SHBG|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.|
|Cellular Location||Secreted. Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis|
|Tissue Location||Isoform 1 and isoform 2 are present in liver and testis|
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This gene encodes a steroid binding protein that was firstdescribed as a plasma protein secreted by the liver but is nowthought to participate in the regulation of steroid responses. Theencoded protein binds each steroid molecule as a dimer formed fromidentical or nearly identical monomers. The use of alternatepromoters and alternatively spliced transcripts have beendescribed. Multiple transcript variants encoding different isoformshave been found for this gene.
Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)Xita, N., et al. Exp. Clin. Endocrinol. Diabetes (2010) In press :Diaz, M., et al. Fertil. Steril. (2010) In press :Hatzi, E., et al. Gynecol. Endocrinol. (2010) In press :Iwasaki, M., et al. Nutr Cancer 62(4):466-475(2010)
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