|Other Names||P2X purinoceptor 1, P2X1, ATP receptor, Purinergic receptor, P2RX1, P2X1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death (By similarity).|
|Cellular Location||Membrane; Multi-pass membrane protein.|
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The product of this gene belongs to the family ofpurinoceptors for ATP. This receptor functions as a ligand-gatedion channel with relatively high calcium permeability. Binding toATP mediates synaptic transmission between neurons and from neuronsto smooth muscle, being responsible, for example, for sympatheticvasoconstriction in small arteries, arterioles and vas deferens.Mouse studies suggest that this receptor is essential for normalmale reproductive function. It is possible that the development ofselective antagonists for this receptor may provide an effectivenon-hormonal male contraceptive pill.
Allsopp, R.C., et al. J. Biol. Chem. 285(43):32770-32777(2010)Harper, M.T., et al. J. Thromb. Haemost. 8(7):1604-1613(2010)Lalo, U., et al. J. Neurochem. 113(5):1177-1187(2010)Varani, K., et al. Cell. Physiol. Biochem. 25 (2-3), 325-336 (2010) :Corriden, R., et al. Sci Signal 3 (104), RE1 (2010) :
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