P2RX1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P51575 |
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Clone Names | 100617299 |
Gene ID | 5023 |
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Other Names | P2X purinoceptor 1, P2X1, ATP receptor, Purinergic receptor, P2RX1, P2X1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | P2RX1 |
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Synonyms | P2X1 |
Function | Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death (By similarity). |
Cellular Location | Membrane; Multi-pass membrane protein. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The product of this gene belongs to the family ofpurinoceptors for ATP. This receptor functions as a ligand-gatedion channel with relatively high calcium permeability. Binding toATP mediates synaptic transmission between neurons and from neuronsto smooth muscle, being responsible, for example, for sympatheticvasoconstriction in small arteries, arterioles and vas deferens.Mouse studies suggest that this receptor is essential for normalmale reproductive function. It is possible that the development ofselective antagonists for this receptor may provide an effectivenon-hormonal male contraceptive pill.
References
Allsopp, R.C., et al. J. Biol. Chem. 285(43):32770-32777(2010)Harper, M.T., et al. J. Thromb. Haemost. 8(7):1604-1613(2010)Lalo, U., et al. J. Neurochem. 113(5):1177-1187(2010)Varani, K., et al. Cell. Physiol. Biochem. 25 (2-3), 325-336 (2010) :Corriden, R., et al. Sci Signal 3 (104), RE1 (2010) :
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