|Other Names||POU domain, class 3, transcription factor 2, Brain-specific homeobox/POU domain protein 2, Brain-2, Brn-2, Nervous system-specific octamer-binding transcription factor N-Oct-3, Octamer-binding protein 7, Oct-7, Octamer-binding transcription factor 7, OTF-7, POU3F2, BRN2, OCT7, OTF7|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||BRN2, OCT7, OTF7|
|Function||Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (By similarity).|
|Tissue Location||Expressed specifically in the neuroectodermal cell lineage|
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Provided below are standard protocols that you may find useful for product applications.
POU3F2 belongs to a large family of transcription factorsthat bind to the octameric DNA sequence ATGCAAAT. Most of theseproteins share a highly homologous region, referred to as the POUdomain, that occurs in several mammalian transcription factors,including the octamer-binding proteins Oct1 (POU2F1; MIM 164175)and Oct2 (POU2F2; MIM 164176) and the pituitary protein Pit1 (PIT1;MIM 173110). Class III POU genes are expressed predominantly in thecentral nervous system (CNS). It is likely that CNS-specifictranscription factors such as these play an important role inmammalian neurogenesis by regulating their diverse patterns of geneexpression (Schreiber et al., 1993 [PubMed 8441633]; Atanasoski etal., 1995 [PubMed 7601453]).
Kobi, D., et al. Pigment Cell Melanoma Res 23(3):404-418(2010)Flammiger, A., et al. J. Invest. Dermatol. 129(4):945-953(2009)Cabos-Siguier, B., et al. Protein Expr. Purif. 64(1):39-46(2009)Lowe, J.K., et al. PLoS Genet. 5 (2), E1000365 (2009) :Potkin, S.G., et al. Schizophr Bull 35(1):96-108(2009)
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