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POU3F2 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P20265
Clone Names 100623171
Peptide ID 100623171
Additional Information
Gene ID 5454
Other Names POU domain, class 3, transcription factor 2, Brain-specific homeobox/POU domain protein 2, Brain-2, Brn-2, Nervous system-specific octamer-binding transcription factor N-Oct-3, Octamer-binding protein 7, Oct-7, Octamer-binding transcription factor 7, OTF-7, POU3F2, BRN2, OCT7, OTF7
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name POU3F2
Synonyms BRN2, OCT7, OTF7
Function Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity).
Cellular Location Nucleus.
Tissue Location Expressed specifically in the neuroectodermal cell lineage
Research Areas
Citations (0)

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POU3F2 belongs to a large family of transcription factorsthat bind to the octameric DNA sequence ATGCAAAT. Most of theseproteins share a highly homologous region, referred to as the POUdomain, that occurs in several mammalian transcription factors,including the octamer-binding proteins Oct1 (POU2F1; MIM 164175)and Oct2 (POU2F2; MIM 164176) and the pituitary protein Pit1 (PIT1;MIM 173110). Class III POU genes are expressed predominantly in thecentral nervous system (CNS). It is likely that CNS-specifictranscription factors such as these play an important role inmammalian neurogenesis by regulating their diverse patterns of geneexpression (Schreiber et al., 1993 [PubMed 8441633]; Atanasoski etal., 1995 [PubMed 7601453]).


Kobi, D., et al. Pigment Cell Melanoma Res 23(3):404-418(2010)Flammiger, A., et al. J. Invest. Dermatol. 129(4):945-953(2009)Cabos-Siguier, B., et al. Protein Expr. Purif. 64(1):39-46(2009)Lowe, J.K., et al. PLoS Genet. 5 (2), E1000365 (2009) :Potkin, S.G., et al. Schizophr Bull 35(1):96-108(2009)

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$ 80.00
Cat# BP16803c
Availability: In Stock
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