|Other Names||Myosin-9, Cellular myosin heavy chain, type A, Myosin heavy chain 9, Myosin heavy chain, non-muscle IIa, Non-muscle myosin heavy chain A, NMMHC-A, Non-muscle myosin heavy chain IIa, NMMHC II-a, NMMHC-IIA, MYH9|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10.|
|Cellular Location||Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Colocalizes with actin filaments at lamellipodia margins and at the leading edge of migrating cells.|
|Tissue Location||In the kidney, expressed in the glomeruli. Also expressed in leukocytes.|
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This gene encodes a myosin IIA heavy chain that containsan IQ domain and a myosin head-like domain. The protein is involvedin several important functions, including cytokinesis, cellmotility and maintenance of cell shape. Defects in MYH9 are thecause of non-syndromic sensorineural deafness autosomal dominanttype 17, Epstein syndrome, Alport syndrome withmacrothrombocytopenia, Sebastian syndrome, Fechtner syndrome andmacrothrombocytopenia with progressive sensorineural deafness.
Arii, J., et al. Nature 467(7317):859-862(2010)Genovese, G., et al. Kidney Int. 78(7):698-704(2010)Tzur, S., et al. Hum. Genet. 128(3):345-350(2010)Bostrom, M.A., et al. Hum. Genet. 128(2):195-204(2010)Oleksyk, T.K., et al. PLoS ONE 5 (7), E11474 (2010) :
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