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PIGP Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P57054 |
|---|---|
| Clone Names | 100617138 |
| Gene ID | 51227 |
|---|---|
| Other Names | Phosphatidylinositol N-acetylglucosaminyltransferase subunit P, Down syndrome critical region protein 5, Down syndrome critical region protein C, Phosphatidylinositol-glycan biosynthesis class P protein, PIG-P, PIGP, DCRC, DSCR5, DSCRC |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PIGP (HGNC:3046) |
|---|---|
| Synonyms | DCRC, DSCR5, DSCRC |
| Function | Part of the glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. |
| Cellular Location | Membrane; Multi-pass membrane protein |
| Tissue Location | Ubiquitous. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an enzyme involved in the first step ofglycosylphosphatidylinositol (GPI)-anchor biosynthesis. TheGPI-anchor is a glycolipid found on many blood cells that serves toanchor proteins to the cell surface. The encoded protein is acomponent of the GPI-N-acetylglucosaminyltransferase complex thatcatalyzes the transfer of N-acetylglucosamine (GlcNAc) fromUDP-GlcNAc to phosphatidylinositol (PI). This gene is located inthe Down Syndrome critical region on chromosome 21 and is acandidate for the pathogenesis of Down syndrome. Alternativelyspliced transcript variants encoding different isoforms have beendescribed.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Ferrando-Miguel, R., et al. Amino Acids 26(3):255-261(2004)Choi, D.K., et al. Mamm. Genome 12(5):347-351(2001)Kinoshita, T., et al. Curr Opin Chem Biol 4(6):632-638(2000)Watanabe, R., et al. EMBO J. 19(16):4402-4411(2000)
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