|Other Names||CST complex subunit STN1, Oligonucleotide/oligosaccharide-binding fold-containing protein 1, Suppressor of cdc thirteen homolog, OBFC1, STN1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.|
|Cellular Location||Nucleus. Chromosome, telomere.|
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Provided below are standard protocols that you may find useful for product applications.
OBFC1 and C17ORF68 (MIM 613129) are subunits of an alphaaccessory factor (AAF) that stimulates the activity of DNApolymerase-alpha-primase (see MIM 176636), the enzyme thatinitiates DNA replication (Casteel et al., 2009 [PubMed 19119139]).OBFC1 also appears to function in a telomere-associated complexwith C17ORF68 and TEN1 (C17ORF106; MIM 613130) (Miyake et al., 2009[PubMed 19854130]).
Levy, D., et al. Proc. Natl. Acad. Sci. U.S.A. 107(20):9293-9298(2010)Miyake, Y., et al. Mol. Cell 36(2):193-206(2009)Wan, M., et al. J. Biol. Chem. 284(39):26725-26731(2009)Casteel, D.E., et al. J. Biol. Chem. 284(9):5807-5818(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)
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