|Other Names||Keratin, type II cytoskeletal 75, Cytokeratin-75, CK-75, Keratin-6 hair follicle, hK6hf, Keratin-75, K75, Type II keratin-K6hf, Type-II keratin Kb18, KRT75, K6HF, KB18|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle.|
|Tissue Location||Highly expressed in hair follicles from scalp. Specifically expressed in the of the hair companion layer follicle, a single layered band of flat and vertically oriented cells between the cuboidal outer root sheath (ORS) cells and the inner root sheath (IRS) that stretches from the lowermost bulb region to the isthmus of the follicle. Also expressed in medullated hairs. In nails, it is almost exclusively present in the nail bed (at protein level).|
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This gene is a member of the type II keratin familyclustered on the long arm of chromosome 12. Type I and type IIkeratins heteropolymerize to form intermediate-sized filaments inthe cytoplasm of epithelial cells. This gene is expressed in thecompanion layer, upper germinative matrix region of the hairfollicle, and medulla of the hair shaft. The encoded protein playsan essential role in hair and nail formation. Variations in thisgene have been associated with the hair disorderspseudofolliculitis barbae (PFB) and loose anagen hair syndrome(LAHS).
Sperling, L.C., et al. J. Cutan. Pathol. 37(2):243-248(2010)Liu, Z.B., et al. Tumori 95(1):53-62(2009)Nofech-Mozes, S., et al. Int. J. Surg. Pathol. 16(4):399-406(2008)Schweizer, J., et al. J. Cell Biol. 174(2):169-174(2006)Roh, C., et al. Physiol. Genomics 19(2):207-217(2004)
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