|Other Names||RCC1 and BTB domain-containing protein 1, Chronic lymphocytic leukemia deletion region gene 7 protein, CLL deletion region gene 7 protein, Regulator of chromosome condensation and BTB domain-containing protein 1, RCBTB1, CLLD7, E45|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in cell cycle regulation by chromatin remodeling.|
|Tissue Location||Ubiquitously expressed.|
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This gene encodes a protein with an N-terminal RCC1 domainand a C-terminal BTB (broad complex, tramtrack and bric-a-brac)domain. In rat, over-expression of this gene in vascular smoothmuscle cells induced cellular hypertrophy. In rat, the C-terminusof RCBTB1 interacts with the angiotensin II receptor-1A. In humans,this gene maps to a region of chromosome 13q that is frequentlydeleted in B-cell chronic lymphocytic leukemia and other lymphoidmalignancies.
Genuneit, J., et al. Clin. Exp. Allergy 39(12):1875-1888(2009)Guo, D.F., et al. J. Biol. Chem. 279(20):21109-21120(2004)Dunham, A., et al. Nature 428(6982):522-528(2004)Solomou, E.E., et al. Leuk. Lymphoma 44(9):1579-1585(2003)Mabuchi, H., et al. Cancer Res. 61(7):2870-2877(2001)
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