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RCBTB1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8NDN9 |
|---|---|
| Clone Names | 110617148 |
| Gene ID | 55213 |
|---|---|
| Other Names | RCC1 and BTB domain-containing protein 1, Chronic lymphocytic leukemia deletion region gene 7 protein, CLL deletion region gene 7 protein, Regulator of chromosome condensation and BTB domain-containing protein 1, RCBTB1, CLLD7, E45 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RCBTB1 |
|---|---|
| Synonyms | CLLD7, E4.5 |
| Function | May be involved in cell cycle regulation by chromatin remodeling. |
| Cellular Location | Nucleus. |
| Tissue Location | Ubiquitously expressed (PubMed:11306461, PubMed:27486781). In the retina, present in the nerve fiber layer and to a lesser extent in the inner and outer plexiform layers (at protein level) (PubMed:27486781). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein with an N-terminal RCC1 domainand a C-terminal BTB (broad complex, tramtrack and bric-a-brac)domain. In rat, over-expression of this gene in vascular smoothmuscle cells induced cellular hypertrophy. In rat, the C-terminusof RCBTB1 interacts with the angiotensin II receptor-1A. In humans,this gene maps to a region of chromosome 13q that is frequentlydeleted in B-cell chronic lymphocytic leukemia and other lymphoidmalignancies.
References
Genuneit, J., et al. Clin. Exp. Allergy 39(12):1875-1888(2009)Guo, D.F., et al. J. Biol. Chem. 279(20):21109-21120(2004)Dunham, A., et al. Nature 428(6982):522-528(2004)Solomou, E.E., et al. Leuk. Lymphoma 44(9):1579-1585(2003)Mabuchi, H., et al. Cancer Res. 61(7):2870-2877(2001)
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