|Other Names||Oxysterol-binding protein-related protein 1, ORP-1, OSBP-related protein 1, OSBPL1A, ORP1, OSBP8, OSBPL1, OSBPL1B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ORP1, OSBP8, OSBPL1, OSBPL1B|
|Function||Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A (PubMed:16176980). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).|
|Cellular Location||Late endosome. Note=Colocalizes with RAB7A, RAB9A and LAMP1 in late endosomes|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the oxysterol-bindingprotein (OSBP) family, a group of intracellular lipid receptors.Most members contain an N-terminal pleckstrin homology domain and ahighly conserved C-terminal OSBP-like sterol-binding domain,although some members contain only the sterol-binding domain.Transcript variants derived from alternative promoter usage and/oralternative splicing exist; they encode different isoforms.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Hsu, Y.H., et al. PLoS Genet. 6 (6), E1000977 (2010) :Rocha, N., et al. J. Cell Biol. 185(7):1209-1225(2009)Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008) :Bjornsson, H.T., et al. Genome Res. 18(5):771-779(2008)
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