|Other Names||Oxysterol-binding protein-related protein 1, ORP-1, OSBP-related protein 1, OSBPL1A, ORP1, OSBP8, OSBPL1, OSBPL1B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ORP1, OSBP8, OSBPL1, OSBPL1B|
|Function||Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A (PubMed:16176980). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).|
|Cellular Location||Late endosome. Note=Colocalizes with RAB7A, RAB9A and LAMP1 in late endosomes|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the oxysterol-bindingprotein (OSBP) family, a group of intracellular lipid receptors.Most members contain an N-terminal pleckstrin homology domain and ahighly conserved C-terminal OSBP-like sterol-binding domain,although some members contain only the sterol-binding domain.Transcript variants derived from alternative promoter usage and/oralternative splicing exist; they encode different isoforms.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Hsu, Y.H., et al. PLoS Genet. 6 (6), E1000977 (2010) :Rocha, N., et al. J. Cell Biol. 185(7):1209-1225(2009)Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008) :Bjornsson, H.T., et al. Genome Res. 18(5):771-779(2008)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.