|Other Names||Taste receptor type 2 member 7, T2R7, Taste receptor family B member 4, TRB4, TAS2R7|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin- positive cells|
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Provided below are standard protocols that you may find useful for product applications.
This gene product belongs to the family of candidate tastereceptors that are members of the G-protein-coupled receptorsuperfamily. These proteins are specifically expressed in the tastereceptor cells of the tongue and palate epithelia. They areorganized in the genome in clusters and are genetically linked toloci that influence bitter perception in mice and humans. Infunctional expression studies, they respond to bitter tastants.This gene maps to the taste receptor gene cluster on chromosome12p13.
Go, Y., et al. Genetics 170(1):313-326(2005)Fischer, A., et al. Mol. Biol. Evol. 22(3):432-436(2005)Zhang, Y., et al. Cell 112(3):293-301(2003)Montmayeur, J.P., et al. Curr. Opin. Neurobiol. 12(4):366-371(2002)Margolskee, R.F. J. Biol. Chem. 277(1):1-4(2002)
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