|Other Names||Phosphate-regulating neutral endopeptidase, 3424-, Metalloendopeptidase homolog PEX, Vitamin D-resistant hypophosphatemic rickets protein, X-linked hypophosphatemia protein, HYP, PHEX, PEX|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probably involved in bone and dentin mineralization and renal phosphate reabsorption.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Lymphocytes and fetal brain; not in adult brain, placenta, skeletal muscle and pancreas; not in adult and fetal heart, lung, liver and kidney|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a transmembraneendopeptidase that belongs to the type II integral membranezinc-dependent endopeptidase family. The protein is thought to beinvolved in bone and dentin mineralization and renal phosphatereabsorption. Mutations in this gene cause X-linkedhypophosphatemic rickets.
Majewski, P.M., et al. J. Biol. Chem. 285(45):34828-34838(2010)Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :Clausmeyer, S., et al. Calcif. Tissue Int. 85(3):211-220(2009)Gaucher, C., et al. Hum. Genet. 125(4):401-411(2009)Strom, T.M., et al. Curr. Opin. Nephrol. Hypertens. 17(4):357-362(2008)
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