|Other Names||Polyadenylate-binding protein 2, PABP-2, Poly(A)-binding protein 2, Nuclear poly(A)-binding protein 1, Poly(A)-binding protein II, PABII, Polyadenylate-binding nuclear protein 1, PABPN1, PAB2, PABP2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation (By similarity).|
|Cellular Location||Nucleus. Cytoplasm Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between the nucleus and the cytoplasm but predominantly found in the nucleus. Its nuclear import may involve the nucleocytoplasmic transport receptor transportin and a RAN-GTP-sensitive import mechanism. Is exported to the cytoplasm by a carrier-mediated pathway that is independent of mRNA traffic Nucleus; nuclear speckle. Colocalizes with SKIP and poly(A) RNA in nuclear speckles (By similarity).|
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This gene encodes an abundant nuclear protein that bindswith high affinity to nascent poly(A) tails. The protein isrequired for progressive and efficient polymerization of poly(A)tails on the 3' ends of eukaryotic genes and controls the size ofthe poly(A) tail to about 250 nt. At steady-state, this protein islocalized in the nucleus whereas a different poly(A) bindingprotein is localized in the cytoplasm. An expansion of thetrinucleotide (GCG) repeat from normal 6 to 8-13 at the 5' end ofthe coding region of this gene leads to autosomal dominantoculopharyngeal muscular dystrophy (OPMD) disease. Multiple splicevariants have been described but their full-length nature is notknown. One splice variant includes introns 1 and 6 but no proteinis formed.
Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)Hurt, J.A., et al. J. Cell Biol. 185(2):265-277(2009)Kuo, H.C., et al. J. Neurol. Sci. 278 (1-2), 21-24 (2009) :Tavanez, J.P., et al. PLoS ONE 4 (7), E6418 (2009) :Maksimova, N.R., et al. Zh Nevrol Psikhiatr Im S S Korsakova 108(6):52-60(2008)
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