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SEPT8 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q92599 |
|---|---|
| Clone Names | 100324014 |
| Gene ID | 23176 |
|---|---|
| Other Names | Septin-8, SEPT8, KIAA0202 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SEPTIN8 (HGNC:16511) |
|---|---|
| Function | Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (PubMed:15116257). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:B0BNF1}. Cytoplasm, cytoskeleton. Synapse {ECO:0000250|UniProtKB:B0BNF1}. Cell projection, axon {ECO:0000250|UniProtKB:B0BNF1}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:B0BNF1}. Presynapse {ECO:0000250|UniProtKB:B0BNF1}. Note=Expressed in axons of immature neurons, localizes to synapses in mature neurons (By similarity). In platelets, found in areas surrounding alpha-granules (PubMed:15116257) {ECO:0000250|UniProtKB:B0BNF1, ECO:0000269|PubMed:15116257} |
| Tissue Location | Widely expressed, including in brain, heart and platelets; most abundant in aorta. Isoform 2 is expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 1 and 3 are highly expressed in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 2 is highly expressed in prostate, testis and ovary Isoform 1 and isoform 3 are expressed at low levels in prostate, testis and ovary. |
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Provided below are standard protocols that you may find useful for product applications.
Background
SEPT8 is a member of the highly conserved septin family.Septins are 40- to 60-kD GTPases that assemble as filamentousscaffolds. They are involved in the organization of submembranousstructures, in neuronal polarity, and in vesicle trafficking(Blaser et al., 2003 [PubMed 12909369]).
References
Souza, T.A., et al. Protein J. 29(5):328-335(2010)Ridruechai, C., et al. Genes Immun. 11(5):416-422(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Xin, X., et al. J. Histochem. Cytochem. 55(11):1089-1094(2007)Steels, J.D., et al. Cell Motil. Cytoskeleton 64(10):794-807(2007)
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