|Other Names||Dolichol phosphate-mannose biosynthesis regulatory protein, Dolichol-phosphate mannose synthase subunit 2, DPM synthase subunit 2, DPM2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulates the biosynthesis of dolichol phosphate- mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Dolichol-phosphate mannose (Dol-P-Man) serves as a donorof mannosyl residues on the lumenal side of the endoplasmicreticulum (ER). Lack of Dol-P-Man results in defective surfaceexpression of GPI-anchored proteins. Dol-P-Man is synthesized fromGDP-mannose and dolichol-phosphate on the cytosolic side of the ERby the enzyme dolichyl-phosphate mannosyltransferase. The proteinencoded by this gene is a hydrophobic protein that contains 2predicted transmembrane domains and a putative ER localizationsignal near the C terminus. This protein associates with DPM1 invivo and is required for the ER localization and stable expressionof DPM1 and also enhances the binding of dolichol-phosphate toDPM1.
Ashida, H., et al. J. Biol. Chem. 281(2):896-904(2006)Suzuki, H., et al. Genome Res. 11(10):1758-1765(2001)Kinoshita, T., et al. Curr Opin Chem Biol 4(6):632-638(2000)Watanabe, R., et al. EMBO J. 19(16):4402-4411(2000)Maeda, Y., et al. EMBO J. 19(11):2475-2482(2000)
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