DPM2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O94777 |
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Clone Names | 100406044 |
Gene ID | 8818 |
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Other Names | Dolichol phosphate-mannose biosynthesis regulatory protein, Dolichol-phosphate mannose synthase subunit 2, DPM synthase subunit 2, DPM2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DPM2 (HGNC:3006) |
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Function | Regulates the biosynthesis of dolichol phosphate-mannose (PubMed:10835346). Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1 (PubMed:10835346). Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N- acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis (PubMed:16162815). May act by regulating the GPI-GNT complex (PubMed:10944123). |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
Dolichol-phosphate mannose (Dol-P-Man) serves as a donorof mannosyl residues on the lumenal side of the endoplasmicreticulum (ER). Lack of Dol-P-Man results in defective surfaceexpression of GPI-anchored proteins. Dol-P-Man is synthesized fromGDP-mannose and dolichol-phosphate on the cytosolic side of the ERby the enzyme dolichyl-phosphate mannosyltransferase. The proteinencoded by this gene is a hydrophobic protein that contains 2predicted transmembrane domains and a putative ER localizationsignal near the C terminus. This protein associates with DPM1 invivo and is required for the ER localization and stable expressionof DPM1 and also enhances the binding of dolichol-phosphate toDPM1.
References
Ashida, H., et al. J. Biol. Chem. 281(2):896-904(2006)Suzuki, H., et al. Genome Res. 11(10):1758-1765(2001)Kinoshita, T., et al. Curr Opin Chem Biol 4(6):632-638(2000)Watanabe, R., et al. EMBO J. 19(16):4402-4411(2000)Maeda, Y., et al. EMBO J. 19(11):2475-2482(2000)
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