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IL28B Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8IZI9
Clone Names 100406296
Peptide ID 100406296
Additional Information
Gene ID 282617
Other Names Interferon lambda-3, IFN-lambda-3, Cytokine Zcyto22, Interleukin-28B, IL-28B, Interleukin-28C, IL-28C, IFNL3, IL28B, IL28C, ZCYTO22
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name IFNL3
Synonyms IL28B, IL28C, ZCYTO22
Function Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
Cellular Location Secreted.
Research Areas
Citations (0)

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This gene encodes a cytokine distantly related to type Iinterferons and the IL-10 family. This gene, interleukin 28A(IL28A), and interleukin 29 (IL29) are three closely relatedcytokine genes that form a cytokine gene cluster on a chromosomalregion mapped to 19q13. Expression of the cytokines encoded by thethree genes can be induced by viral infection. All three cytokineshave been shown to interact with a heterodimeric class II cytokinereceptor that consists of interleukin 10 receptor, beta (IL10RB)and interleukin 28 receptor, alpha (IL28RA).


Lindh, M., et al. Hepatology 52(5):1860-1861(2010)Pineda, J.A., et al. Clin. Infect. Dis. 51(7):788-795(2010)Grebely, J., et al. Hepatology 52(4):1216-1224(2010)Stattermayer, A.F., et al. Clin. Gastroenterol. Hepatol. (2010) In press :Iwata, R., et al. J. Viral Hepat. (2010) In press :

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$ 80.00
Cat# BP16853a
(40 western blots)
Availability: In Stock
Bulk Size
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