|Other Names||Interferon lambda-3, IFN-lambda-3, Cytokine Zcyto22, Interleukin-28B, IL-28B, Interleukin-28C, IL-28C, IFNL3, IL28B, IL28C, ZCYTO22|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||IL28B, IL28C, ZCYTO22|
|Function||Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.|
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This gene encodes a cytokine distantly related to type Iinterferons and the IL-10 family. This gene, interleukin 28A(IL28A), and interleukin 29 (IL29) are three closely relatedcytokine genes that form a cytokine gene cluster on a chromosomalregion mapped to 19q13. Expression of the cytokines encoded by thethree genes can be induced by viral infection. All three cytokineshave been shown to interact with a heterodimeric class II cytokinereceptor that consists of interleukin 10 receptor, beta (IL10RB)and interleukin 28 receptor, alpha (IL28RA).
Lindh, M., et al. Hepatology 52(5):1860-1861(2010)Pineda, J.A., et al. Clin. Infect. Dis. 51(7):788-795(2010)Grebely, J., et al. Hepatology 52(4):1216-1224(2010)Stattermayer, A.F., et al. Clin. Gastroenterol. Hepatol. (2010) In press :Iwata, R., et al. J. Viral Hepat. (2010) In press :
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