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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   TRIM25 Antibody (Center) Blocking Peptide   

TRIM25 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q14258
Clone Names 100408313
Peptide ID 100408313
Additional Information
Gene ID 7706
Other Names E3 ubiquitin/ISG15 ligase TRIM25, 632n3, Estrogen-responsive finger protein, RING finger protein 147, Tripartite motif-containing protein 25, Ubiquitin/ISG15-conjugating enzyme TRIM25, Zinc finger protein 147, TRIM25, EFP, RNF147, ZNF147
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM25
Synonyms EFP, RNF147, ZNF147
Function Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs.
Cellular Location Cytoplasm. Note=Colocalized with DDX58 at cytoplasmic perinuclear bodies
Tissue Location Ubiquitous..
Research Areas
Citations (0)

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The protein encoded by this gene is a member of thetripartite motif (TRIM) family. The TRIM motif includes threezinc-binding domains, a RING, a B-box type 1 and a B-box type 2,and a coiled-coil region. The protein localizes to the cytoplasm.The presence of potential DNA-binding anddimerization-transactivation domains suggests that this protein mayact as a transcription factor, similar to several other members ofthe TRIM family. Expression of the gene is upregulated in responseto estrogen, and it is thought to mediate estrogen actions inbreast cancer as a primary response gene.


Dai, H., et al. Oncol. Rep. 23(3):795-799(2010)Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :Gack, M.U., et al. Cell Host Microbe 5(5):439-449(2009)Ludwig, S., et al. Cell Host Microbe 5(5):420-421(2009)Dai, H., et al. Oncol. Rep. 21(2):395-401(2009)

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$ 80.00
Cat# BP16857c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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