|Other Names||Tripartite motif-containing protein 26, Acid finger protein, AFP, RING finger protein 95, Zinc finger protein 173, TRIM26, RNF95, ZNF173|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA- encoded pattern-recognition receptors (PRRs). Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1.|
|Cellular Location||Cytoplasm. Nucleus. Note=Viral infection mediates TRIM26 nuclear translocation|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of thetripartite motif (TRIM) family. The TRIM motif includes threezinc-binding domains, a RING, a B-box type 1 and a B-box type 2,and a coiled-coil region. The protein localizes to cytoplasmicbodies. Although the function of the protein is unknown, the RINGdomain suggests that the protein may have DNA-binding activity. Thegene localizes to the major histocompatibility complex (MHC) classI region on chromosome 6.
Cree, B.A., et al. PLoS ONE 5 (6), E11296 (2010) :Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :Males, S., et al. Antivir. Ther. (Lond.) 12(5):797-803(2007)Reymond, A., et al. EMBO J. 20(9):2140-2151(2001)Rahman, A., et al. J. Biol. Chem. 273(25):15395-15403(1998)
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