|Other Names||Syndecan-4, SYND4, Amphiglycan, Ryudocan core protein, SDC4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).|
|Cellular Location||Isoform 1: Membrane; Single- pass type I membrane protein. Secreted. Note=Shedding of the ectodomain produces a soluble form.|
|Tissue Location||Expressed in epithelial and fibroblastic cells.|
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The protein encoded by this gene is a transmembrane (typeI) heparan sulfate proteoglycan that functions as a receptor inintracellular signaling. The encoded protein is found as ahomodimer and is a member of the syndecan proteoglycan family. Thisgene is found on chromosome 20, while a pseudogene has been foundon chromosome 22.
Buhligen, J., et al. J. Cell. Physiol. 225(3):905-914(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Carvallo, L., et al. J. Biol. Chem. 285(38):29546-29555(2010)Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010)Hallberg, G., et al. Reprod. Biol. Endocrinol. 8, 35 (2010) :
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