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SLC2A9 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NRM0 |
|---|---|
| Clone Names | 100318092 |
| Gene ID | 56606 |
|---|---|
| Other Names | Solute carrier family 2, facilitated glucose transporter member 9, Glucose transporter type 9, GLUT-9, SLC2A9, GLUT9 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC2A9 {ECO:0000303|PubMed:10860667, ECO:0000312|HGNC:HGNC:13446} |
|---|---|
| Function | High-capacity urate transporter, which may play a role in the urate reabsorption by proximal tubules (PubMed:18327257, PubMed:28083649, PubMed:22647630, PubMed:18701466, PubMed:36749388). May have a residual high-affinity, low-capacity glucose and fructose transporter activity (PubMed:18842065, PubMed:18327257, PubMed:18701466). Transports urate at rates 45- to 60-fold faster than glucose (PubMed:18842065). Does not transport galactose (PubMed:28083649). May mediate small uptake of adenine but not of other nucleobases (PubMed:22647630). |
| Cellular Location | [Isoform 1]: Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein |
| Tissue Location | [Isoform 1]: Most strongly expressed in basolateral membranes of proximal renal tubular cells, liver and placenta. Also detected in lung, blood leukocytes, heart skeletal muscle and chondrocytes from articular cartilage. Detected in kidney membrane (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the SLC2A facilitativeglucose transporter family. Members of this family play asignificant role in maintaining glucose homeostasis. The encodedprotein may play a role in the development and survival ofchondrocytes in cartilage matrices. Two transcript variantsencoding distinct isoforms have been identified for this gene.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Facheris, M.F., et al. J. Mol. Neurosci. (2010) In press :Houlihan, L.M., et al. Hum. Mol. Genet. 19(11):2321-2330(2010)Urano, W., et al. Ann. Rheum. Dis. 69(5):932-933(2010)Tabara, Y., et al. Am. J. Nephrol. 32(3):279-286(2010)
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