|Other Names||Microspherule protein 1, 58 kDa microspherule protein, Cell cycle-regulated factor p78, INO80 complex subunit J, MCRS2, MCRS1, INO80Q, MSP58|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homopolymer poly(G) and poly(U) (PubMed:16571602).|
|Cellular Location||Nucleus. Nucleus, nucleolus Cytoplasm. Note=In microspherules in the nucleolus.|
|Tissue Location||Detected in testis, and at lower levels in spleen, thymus, prostate, uterus, small intestine, colon and leukocytes|
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Provided below are standard protocols that you may find useful for product applications.
MCRS1 modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. May be an inhibitor of TERT telomerase activity.
Lin, W., et al. J. Cell. Mol. Med. 13 (11-12), 4608-4622 (2009) :Shi, H., et al. Cancer Sci. 100(9):1585-1590(2009)Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Wu, J.L., et al. BMC Cell Biol. 10, 9 (2009) :Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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